Source: Medical News Today
Levels of HIV come down in HIV-positive women who are also infected with herpes simplex and are being treated for it with the antiviral drug valacyclovir.
These are the findings of a study published in today's New England Journal of Medicine.
The research was conducted in Burkina-Faso in Africa and took the form of a randomized, double-blind placebo-controlled trial.
Valocyclovir is marketed by GlaxoSmithKline as Valtrex.
Dr Nicolas Nagot of the London School of Hygiene and Tropical Medicine and colleagues found that treating herpes simplex 2 (HSV-2) infections with valocyclovir reduced levels of HIV-1 RNA in both the blood plasma and the genital mucosa, with the latter being more significant.
And this effect seemed to get stronger over the three months of the study.
Once a woman has herpes, the risk of getting HIV is increased and other research studies have shown that when HSV-2 is present it increases the amount of HIV-1 in plasma and genital mucosa.
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Having genital herpes can increase the risk of being infected with HIV, the virus that causes AIDS, and it can cause serious problems for people living with HIV.
People who have genital herpes sores are more likely to be infected with HIV during intercourse. When you develop a sore, your immune system tries to heal it, so there are many immune cells concentrated in that spot. Those are the cells that HIV infects. If HIV in semen, vaginal fluid, or blood comes in contact with a herpes sore, the risk for infection is high.
HIV and the herpes virus are a troublesome duo. One can worsen the effects of the other. Research shows that when the herpes virus is active, it may cause HIV to make more copies of itself (the process called replication) than it would otherwise. The more HIV replicates, the more of the body's infection-fighting cells it destroys, eventually leading to AIDS (acquired immune deficiency syndrome).
People infected with both HIV and the herpes virus may have longer-lasting, more frequent, and more severe outbreaks of herpes symptoms, because a weakened immune system can't keep the herpes virus under control as well as a healthy immune system can.
http://www.webmd.com/genital-herpes/guide/risk-HIV
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