Thursday, September 27, 2007

Canada issues compulsory licence for HIV/AIDS drug export to Rwanda, in first test of WTO procedure

Source: BRIDGES Weekly Trade News Digest

Rwanda last week came one step closer to becoming the first nation to use a WTO procedure designed to allow developing countries to import cut-price copies of patented medicines, when Canadian patent authorities issued a compulsory licence authorising the generic production of a patented HIV/AIDS drug for export to the central African country.

"This is big step forward in finally getting at least one affordable medicine from Canada to a developing country in need," said Richard Elliott, Executive Director of the Canadian HIV/AIDS Legal Network. However, noting that it had already been three years since Canada introduced a legal system for making such exports possible, he said "it's also a wake-up call" about the need to simplify the process to make it more efficient and effective.

The Canadian Intellectual Property Office (CIPO) cleared large generic pharmaceutical company Apotex to manufacture and deliver 260,000 packs of Apo-Triavir at cost to Rwandan health authorities. This would be enough to treat 21,000 AIDS patients for a year.

Rwandan WTO delegate Edouard Bizumuremyi told Bridges he was delighted with the development and said Rwanda had been "waiting for this."

The authorisation follows Rwanda's July notification to the WTO that it wanted to import that quantity of the medicine from Canada (see BRIDGES Weekly, 25 July 2007), becoming the first country to try to import generics under a WTO procedure criticised as too complex to be effective. (...)

Click here to read the entire article.

Thursday, September 20, 2007

New journal received: AIDS Patient Care and STDs, Vol. 21, no 8, August 2007

Free access to this issue!

Case Report: Immune Reconstitution Inflammatory Syndrome Associated with Disseminated Mycobacterial Infection in Patients with AIDS
Felipe Francisco Tuon, Grace Carvajal Mulatti, Walkyria Pereira Pinto, Francisco Oscar De Siqueira Franca, Ronaldo Cesar Gryschek
pp. 527-532.
Full Text PDF

TORO: Ninety-Six-Week Virologic and Immunologic Response and Safety Evaluation of Enfuvirtide with an Optimized Background of Antiretrovirals
Jacques Reynes, Keikawus Arastéh, Bonaventura Clotet, Calvin Cohen, David A. Cooper, Jean-François Delfraissy, Joseph J. Eron, Keith Henry, Christine Katlama, Daniel R. Kuritzkes, Jacob P. Lalezari, Joep Lange, Adriano Lazzarin, Julio S.G. Montaner, Mark Nelson, Mary O' Hearn, Hans-Jürgen Stellbrink, Benoit Trottier, Sharon L. Walmsley, Neil E. Buss, et al.
pp. 533-543.
Full Text PDF

Utility of Repeat Genotypic Resistance Testing and Clinical Response in Patients with Three Class Resistance and Virologic Treatment Failure
Sheila M. Badri, Oluwatoyin M. Adeyemi, Blake E. Max, Bala N. Hota, David E. Barker
544-550.
Full Text PDF

Attitudes and Perceptions of AIDS Clinical Trials Group Site Coordinators on HIV Clinical Trial Recruitment and Retention: A Descriptive Study
William D. King, Donna Defreitas, Kimberly Smith, Janet Andersen, Lisa Patton Perry, Toyin Adeyemi, Jennifer Mitty, Jan Fritsche, Carrie Jeffries, Melvin Littles, Margaret Fischl, Gregory Pavlov, Donna Mildvan, Underrepresented Populations Committee of the Adult AIDS Clinical Trials Group (AACTG)
pp. 551-563.
Full Text PDF

Adherence, Drug Use, and Treatment Failure in a Methadone-Clinic–Based Program of Directly Administered Antiretroviral Therapy
Gregory M. Lucas, B. Anna Mullen, Mary E. McCaul, Paul J. Weidle, Shannon Hader, Richard D. Moore
pp. 564-574.
Full Text PDF

Characteristics of a Sample of Men Who Have Sex with Men, Recruited from Gay Bars and Internet Chat Rooms, Who Report Methamphetamine Use
Scott D. Rhodes, Kenneth C. Hergenrather, Leland J. Yee, Emily Knipper, Aimee M. Wilkin, Morrow R. Omli
pp. 575-583.
Full Text PDF

The Effect of Perceived Stigma from a Health Care Provider on Access to Care Among a Low-Income HIV-Positive Population
Janni J. Kinsler, Mitchell D. Wong, Jennifer N. Sayles, Cynthia Davis, William E. Cunningham
pp. 584-592.
Full Text PDF

Inequality and Unwillingness to Care for People Living with HIV/AIDS: A Survey of Medical Professionals in Southeast China
Guoxi Cai, Kazuhiko Moji, Sumihisa Honda, Xiaonan Wu, Konglai Zhang
pp. 593-601.
Full Text PDF

Antiviral Briefs
pp. 602-605.
Full Text PDF

Drug Developments and STD News
pp. 606-608.
Full Text PDF

George Michael cuts HIV interview

Source: BBC News

Pop star George Michael has asked for an interview in which he discusses his fears of having HIV to be removed from a forthcoming BBC programme. The BBC has confirmed the interview will no longer feature in the documentary, Stephen Fry: HIV and Me.

Michael's former partner, Anselmo Feleppa, died of an Aids-related illness in 1995.

"On reflection, he felt it was too close and too personal a journey," said a spokesman for the singer, 44.

He added: "It was too personal for Anselmo's family to revisit."

'No tests'
When the documentary was launched in July, the BBC revealed details of Michael's interview.
"George says he does not believe in tests," said producer Ross Wilson. "He says he finds the wait for results too harrowing and that he hasn't had a test since at least 2004 due to his fears it might be positive."

The two-part programme will examine how HIV is spreading and show Fry taking an HIV test himself. Michael is still set to appear in this year's festive edition of Catherine Tate's BBC comedy programme. (...)

Wednesday, September 19, 2007

HIV sequences cannot prove guilt

Source: NewScientist News Service

People infected with HIV might well want to know who gave it to them - but the genetic sequence of their virus won't tell them.

The virus is now routinely sequenced in each infected person to uncover drug-resistance genes, but virus sequences have also been used in several high-profile court cases by lawyers seeking to show who infected whom. This has led some HIV carriers to wonder if they might be able to do the same.

"The data won't work for that," warns Deenan Pillay of University College London - because HIV evolves too fast. This means that even though the viruses from two people may look similar, other local viruses may even be more alike. Analysing them can't show whether A infected B or vice versa, whether it went through a third person or whether both were infected by another person (BMJ, DOI: 10.1136/bmj.39315.398843.BE).

However, the British database - now the world's largest collection of viral sequences from a national epidemic - could answer other important questions. For example, it could tell us whether certain strains tend to spread among certain risk groups, or where the super-spreaders of HIV are.

From issue 2621 of New Scientist magazine, 19 September 2007, page 5

New book in the library: HIV Reference Manual

Cairns, Gus (ed.) HIV reference manual
London, NAM Publications, 2007
C 200 HIV 2007
"HIV is more than a medical condition and the HIV Reference Manual is your guide to understanding the complex picture of HIV. It explains the wider interplay of social cultural, economic and legal factors that impact on people living with HIV and those working to support them" (From: http://www.aidsmap.com/cms1230954.asp).

Key topics include:

- benefits - helping people with HIV understand their entitlements
- the epidemiology of HIV
- HIV and the law – major update on confidentiality, disclosure and medical professional standards and immigration law
- HIV in 2007 – updated analysis of the UK and global
- HIV statistics
- helping people get the most out of the services available
- how HIV status affects asylum applications – the rights of asylum seekers explained, including rights to medical treatment on the NHS
- the impact of HIV on the communities most affected
- the latest prevention research – new technologies and strategies, including the debate on circumcision
- quality of life – how HIV may impact upon mental health rights under the Disability Discrimination Act
- women & HIV

New Issue of AIDS Care: Vol. 19, no 7, August 2007

AIDS Care - Psychological and Socio-medical Aspects of AIDS/HIV
In this issue:

Original Articles

Is AIDS chronic or terminal? The perceptions of persons living with AIDS and their informal support partners
pp. 835 – 843
Authors: C. P. Hoy-Ellis; K. I. Fredriksen-Goldsen
Abstract

Gender relations in the context of HIV/AIDS in rural South Africa
pp. 844 – 849
Authors: Catherine Ndinda; Ufo Okeke Uzodike; Chiweni Chimbwete; Robert Pool
Abstract

To determine factors in an initiation of a same-sex relationship in rural China: using ethnographic decision model
pp. 850 – 857
Authors: W. C. W. Wong; T. S. K. Kong
Abstract

The social epidemiology of HIV transmission among African American women who use drugs and their social network members
pp. 858 – 865
Authors: M. Miller; C. T. Korves; T. Fernandez
Abstract

Coping with AIDS-related bereavement in KwaZulu-Natal, South Africa
pp. 866 – 870
Author: C. Demmer
Abstract

Local understanding of an HIV vaccine and its relationship with HIV-related stigma in the Dominican Republic
pp. 871 – 877
Authors: C. Barrington; L. Moreno; D. Kerrigan
Abstract

Health-seeking behaviour for sexually transmitted infections and HIV testing among female sex workers in Vietnam
pp. 878 – 887
Authors: A. D. Ngo; E. A. Ratliff; S. A. McCurdy; M. W. Ross; C. Markham; H. T. B. Pham
Abstract

Knowledge and attitudes of nursing students toward patients living with HIV/AIDS (PLHIV): A Turkish perspective
pp. 888 – 894
Authors: H. A. Bekta; Ö. Kulakaç
Abstract

Using the theory of planned behaviour to understand the motivation to learn about HIV/AIDS prevention among adolescents in Tigray, Ethiopia
pp. 895 – 900
Authors: H. Gebreeyesus Hadera; Henk Boer; W. A. J. M. Kuiper
Abstract

HIV-related traumatic stress symptoms in AIDS caregiving family dads
pp. 901 – 909
Authors: R. G. Wight; K. P. Beals; D. Miller-Martinez; D. A. Murphy; C. S. Aneshensel
Abstract

Care centre visits to married people living with HIV: An indicator for measuring AIDS-related stigma & discrimination
pp. 910 – 915
Authors: D. A. Green; S. Devi; L. S. Paulraj
Abstract

Comprehension of sexual situations and its relationship to risky decisions by young adults
pp. 916 – 922
Authors: V. L. Patel; N. A. Yoskowitz; D. R. Kaufman
Abstract

Quality of life in HIV-positive Brazilians: application and validation of the WHOQOL-HIV, Brazilian version
pp. 923 – 930
Authors: R. R. Zimpel; M. P. Fleck
Abstract

Sex work and risk behaviour among HIV-negative gay men
pp. 931 – 934
Authors: G. Prestage; L. Mao; F. Jin; A. Grulich; J. Kaldor; S. Kippax
Abstract

Return to post-test counselling by out-of-treatment injecting drug users participating in a cross-sectional survey in north Vietnam
pp. 935 – 939
Authors: A. Bergenstrom; V. Go; L. V. Nam; B. T. Thuy; D. D. Celentano; C. Frangakis; V. M. Quan
Abstract

Characteristics of bisexually active men in the Seropositive Urban Mens' Study (SUMS)
pp. 940 – 946
Authors: A. O'Leary; D. W. Purcell; R. H. Remien; H. E. Fisher; P. S. Spikes
Abstract

Contact the library to request copies of articles.

New Strategy Could Dramatically Slow The Spread Of HIV

Source: Science daily

Giving a daily antiretroviral pill to people to prevent HIV could profoundly slow the spread of the infection in sub-Saharan Africa, where it is a full-blown epidemic, University of Pittsburgh School of Medicine researchers report.

Published by the Public Library of Science in the Sept. 19 issue of PLoS One, the findings are based on a mathematical model developed by the researchers to predict the public-health impact of pre-exposure chemoprophylaxis (PrEP) -- an HIV prevention strategy that uses antiretroviral drugs, currently given in combination to treat HIV-positive individuals, to stop the infection from occurring in the first place.

Through the model, the research team predicts that PrEP, targeted to those at highest behavioral risk, could have a major impact on public health, potentially preventing 3.2 million cases of HIV in southern sub-Saharan Africa alone in 10 years. Sub-Saharan Africa, the epicenter of the HIV/AIDS global epidemic, contains almost 63 percent of the world's HIV-infected population, totaling about 22.4 million adults.

Click here to read the entire article.
The article plublished in PLoS One is available here

Tuesday, September 18, 2007

Voluntary HIV-screening for all adult male inpatients at hospitals

Source: Channel News Asia
By Julia Ng, Channel NewsAsia | Posted: 18 September 2007

SINGAPORE: By year's end, all adult male patients admitted to hospitals will be asked if they would like to take a HIV-screening test.

Health Minister Khaw Boon Wan told Parliament on Tuesday he is also changing the Infectious Diseases Act soon so that no one will be able to claim ignorance of one's HIV-positive status as defence against charges of high-risk behaviour.

He said: "All individuals who engage in high-risk sexual behaviour must go for regular HIV-testing. The Infectious Diseases Act makes it an offence for someone who is HIV-positive to have sex without informing his sexual partner of his HIV status. I will soon come to this House to amend the Act to clarify that ignorance of one's HIV status will not be a defence for those who engage in high-risk sexual behaviour."

There are 3,338 known HIV-infected patients in Singapore, with 278 infected in the first eight months of this year. But what is worrying, Mr Khaw said, is the prevalence of undiagnosed HIV.

Click here to read the entire article

Friday, September 14, 2007

Number of Partners Doesn't Explain Gay HIV Rate

Source: HealthDay News
Gay, straight men equally prone to unprotected sex, research shows

By Steven Reinberg
HealthDay Reporter


THURSDAY, Sept. 13 (HealthDay News) -- The HIV epidemic among gay men can't be explained by their number of sexual partners, U.S. researchers report.

More than half the new HIV infections diagnosed in the United States in 2005 were among gay men, a team at the University of Washington, Seattle, noted. In addition, as many as one in five gay men living in cities may be HIV-positive.

But the sexual behaviors of gay and heterosexual men in the United States may not be as different as most people think, the researchers said. In fact, two surveys found that most gay men have a similar rate of sex with unprotected partners compared to straight men or women.

"Just because gay men continue to have much higher levels of HIV, we can't jump to the conclusion that that means that they are promiscuous or that prevention messages aren't working," said lead researcher Steven Goodreau, an assistant professor of anthropology.

In the study, Goodreau and a colleague, Dr. Matthew R. Golden, analyzed data from two large population-based surveys. Using those figures, they estimated how many sex partners gay men and straight men and women have, and what number of gay men have either insertive or receptive anal sex, or both.

The report is published in the Sept. 12 online edition of Sexually Transmitted Infections. (Access to abstract)

Click here to read the article.

New issue of the Journal of HIV/AIDS & Social services (Vol. 6, no 3)

The Journal of HIV/AIDS & Social Services provides a forum in which social workers and other professionals in the field of HIV/AIDS work can access the latest research and techniques in order to provide effective social, educational, and clinical services to all individuals affected by HIV/AIDS. From best practices and advice on case management to evaluations of the impact of various legislation and social policy decisions, this journal will keep you at the forefront of the field!

In this issue:

Attitudes, Knowledge, Behavior in the Context of HIV/AIDS Stigma
pp. 1 - 4
Nathan L. Linsk PhD, Dorie J. Gilbert PhD

Opening Up Windows When Clients Keep Closing Doors: Key Elements in Engaging HIV-Positive Individuals in Prevention Interventions
pp. 5 - 28
Sheri B. Kirshenbaum PhD, Rogerio M. Pinto PhD, Jacqueline Correale MPH et all.

Understanding Motivations for Sex Among Detained Youth: Implications for HIV Prevention Programs
pp. 29 - 41
Dexter R. Voisin PhD, Laura F. Salazar PhD, Richard A. Crosby PhD, Ralph J. DiClemente PhD

Extending the Use of the 40-Item HIV-Stigma Scale to Older Adults: An Examination of Reliability and Validity
pp. 43 - 54
Charles A. Emlet PhD, ACSW

The Impact of HIV-Related Stigma on HIV Care and Prevention Providers
pp. 55 - 73
Michael Reece PhD, MPH, Amanda E. Tanner PhD, MPH, Stephen E. Karpiak PhD, Kate Coffey PhD, MSc

Guyanese Health Care Providers' HIV-Related Experiences, Attitudes, and Readiness to Provide Care
pp. 75 - 96
Cynthia Cannon Poindexter MSW, PhD

A Comparison of Grief Reactions in Cancer, HIV/AIDS, and Suicide Bereavement
pp. 97 - 112
James A. Houck PhD

Contact the library to request copies of articles.

Peru blood banks face HIV crisis

Source: BBC News

Dozens of blood banks in Peru have been closed after at least four people were infected with the HIV virus through contaminated transfusions.
The government said all 240 of the country's facilities would be thoroughly screened, amid what is being described as a national emergency. The patients were all infected at a hospital in the port city of Callao. Officials insisted Peru's blood banks met international standards and urged people to continue giving blood.

"We do not want people to panic, what we have to do is be more careful, strengthen our care [of patients]," said Health Minister Carlos Vallejos.

Public alarm

The crisis was prompted after 44-year-old Judith Rivera contacted the media earlier this week to say she had been infected with HIV during a routine operation. Mrs Rivera, a mother of four, said she was taking legal action to claim compensation.

"What is done is done, as they say, and a life has no price tag," she said during a news conference.

Health officials later revealed that three other patients had been infected with the virus after having blood transfusions at the same hospital - one of them a child aged 11 months.

The Washington-based Pan American Health Organization says its latest figures show that up to a quarter of the blood in Peru's banks is not properly screened. In a further blow to the health system, officials also confirmed that 30 patients who attended a dialysis treatment centre had been infected with Hepatitis C. The BBC's Dan Collyns, in Lima, says Peruvians are alarmed and are avoiding public hospitals. He says the government's response to the crisis is unlikely to restore public confidence in the country's flagging health service.

European researchers develop method of calculating short-term risk of HIV disease progression

Source: AIDSMAP

A new HIV risk score can accurately calculate the short term risk of HIV disease progression, according to researchers who have tested it in a cohort of 5150 HIV-infected people. The research is published in the September edition of AIDS.

The researchers hope the scoring system – which will soon be available on the web – will make treatment decisions easier for both patients and clinicians.

Other prognostic HIV scores have been developed but have tended to be designed to predict long-term clinical progression in patients before they have started antiretroviral therapy. They have also not used routinely measured lab values.

The new tool, called the EuroSIDA risk score, has been designed to be used in people already on anti-HIV treatment and calculates the risk of disease progression in the short-term, for example three, six or twelve months. (...)

Click here to read the entire article

Tuesday, September 04, 2007

New Issue of AIDS Education and Prevention (Vol. 19, no 4, August 2007)

In this issue:


Focusing HIV Prevention on Those Most Likely to Transmit the Virus
Authors: Gary R. West, Amy L. Corneli, Kim Best, Katie M. Kurkjian and William Cates Jr.
pp. 275-288
Abstract

Interaction of Cognitive Performance and Knowing Someone Who Has Died from AIDS on HIV Risk Behaviors
Authors: Mary M. Mitchell, S. Geoff Severtson and William W. Latimer
pp. 289-297
Abstract

HIV–Related Communication and Perceived Norms: An Analysis of the Connection Among Injection Drug Users
Authors: Melissa A. Davey–Rothwell and Carl A. Latkin
pp. 298-309
Abstract

Changes in Sexual Behavior during a Safety and Feasibility Trial of a Microbicide/Diaphragm Combination: An Integrated Qualitative and Quantitative Analysis
Authors: Greg Guest, Laura Johnson, Holly Burke, Reathe Rain-Taljaard, Lawrence Severy, Claire von Mollendorf and Lut Van Damme
pp. 310-320
Abstract

Current Sexual Activity and Risky Sexual Behavior in Older Men With or At Risk for HIV Infection
Authors: Nina A. Cooperman, Julia H. Arnsten and Robert S. Klein
pp. 321-333
Abstract

Sexual Behaviors of Individuals With HIV Living in South India: A Qualitative Study
Authors: A.K. Sri Krishnan, Ellen Hendriksen, Snigda Vallabhaneni,
pp. 334-345
Abstract

Structural Violence Against Kothi–Identified Men Who Have Sex with Men in Chennai, India: A Qualitative Investigation
Authors: Venkatesan Chakrapani, Peter A. Newman, Murali Shunmugam,
pp. 346-364
Abstract